As inconsistent as the Americans have been throughout the year, there are far too many holes in the Bolivian backline and a lack of cohesion among the South Americans.
The USA enters this tournament ranked 11th by FIFA, facing heightened expectations at the Copa America.
They return to the competition for the first time since 2016, where they hosted and achieved a fourth-place finish, their best result in the tournament's history.
Bolivia, ranked 84th and the lowest-seeded team in CONMEBOL, is not expected to perform strongly, having lost their last three international matches by a total score of 7-1.
Antonio Carlos Zago, who won the Copa America as a player with Brazil in 1999, faces challenges in his debut international managerial role, having lost five of his seven matches in charge so far.
Prediction: Bolivia+2
USA vs Bolivia stream and TV listing
Anguilla:Csport.tv
Bangladesh:T Sports
International:Score808 808ball